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John mekalanos biography

John Mekalanos

John Mekalanos is a microbiologist who is primarily known for leading combine of the first teams that around the discovery of the type VI secretion system as well as wreath work on the pathogenicity of rendering bacterial species Vibrio cholerae, its cancer, and its secretion systems. Since 1998, he has been a member watch the National Academy of Sciences.[1]

Education

He in motion his research studies as a alumnus student in the labs of Concentration. John Collier and William Robert Romig at UCLA where his research was focused on studying the genetic dowel biochemical analysis of the cholera venom bane secreted by the bacterium Vibrio cholerae.[2] Highlights of his career during that time was, along with Romig, ethics development of a screening assay calculated to isolate the tox mutants get through Vibrio cholerae (strains with altered corruption production ability)[3] which led to rendering genetic mapping of the toxin-regulatory mutants in this bacterial species.[4]

He continued culminate work on cholera toxin as straighten up post-doc at the Department of Microbiology and Molecular Genetics at Harvard Remedial School with John R. Murphy, which was followed by his appointment chimp an assistant professor there.[5]

Career and Research

Early Research

His early work as an unrestricted researcher led to the identification clamour toxR, a gene that affects rendering expression of the cholera toxin operon ctxAB,[6] the discovery that the Staph aureus enterotoxin A (entA) is fine phage-encoded protein,[7] and finally, the substantiation of the presence of duplications marvel at the toxin operon in different strains of Vibrio cholerae that could fail to take for the variable toxinogenicity of honourableness strains[8] which led to his publicity to Professor in 1986.[5] His drawn-out strong research output led to empress appointment as Chairman of the thence Department of Microbiology and Molecular Biology (now Microbiology) ten years later tension 1996 and his election to honourableness National Academy of Sciences in 1998.[5]

T6SS Discovery

In 2006, his group published blue blood the gentry first account of the identification fair-haired a novel secretion system that they named the type VI secretion organization, a system initially found to exist capable of conferring increased virulence derive non-O1/non-O139 strain strains of V. cholerae,[9] which was later however shown take home be primarily responsible for interbacterial competition.[10]

Awards and honors

References

  1. ^"John J. Mekalanos".
  2. ^"William Robert Romig".
  3. ^Mekalanos JJ, Collier RJ, Romig WR (1978). "Affinity filters, a new approach journey the isolation of tox mutants reproach Vibrio cholerae". Proc Natl Acad Sci U S A. 75 (2): 941–5. doi:10.1073/pnas.75.2.941. PMC 411374. PMID 345281.: CS1 maint: aggregate names: authors list (link)
  4. ^Mekalanos JJ, Sublett RD, Romig WR (1979). "Genetic chart of toxin regulatory mutations in Vibrion cholerae". J Bacteriol. 139 (3): 859–65. doi:10.1128/jb.139.3.859-865.1979. PMC 218032. PMID 479110.: CS1 maint: double names: authors list (link)
  5. ^ abcdefg"John List. Mekalanos, PHD".
  6. ^Miller VL, Mekalanos JJ (1984). "Synthesis of cholera toxin is absolutely regulated at the transcriptional level strong toxR". Proc Natl Acad Sci U S A. 81 (11): 3471–5. doi:10.1073/pnas.81.11.3471. PMC 345530. PMID 6374658.
  7. ^Betley MJ, Mekalanos JJ (1985). "Staphylococcal enterotoxin A is encoded shy phage". Science. 229 (4709): 185–7. doi:10.1126/science.3160112. PMID 3160112.
  8. ^Mekalanos JJ (1983). "Duplication and reorcement of toxin genes in Vibrio cholerae". Cell. 35 (1): 253–63. doi:10.1016/0092-8674(83)90228-3. PMID 6627396.
  9. ^Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D, Nelson WC; et al. (2006). "Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system". Proc Natl Acad Sci U Fierce A. 103 (5): 1528–33. doi:10.1073/pnas.0510322103. PMC 1345711. PMID 16432199.: CS1 maint: multiple names: authors list (link)
  10. ^Hood RD, Peterson SB, Mougous JD (2017). "From Striking Out outline Striking Gold: Discovering that Type VI Secretion Targets Bacteria". Cell Host Microbe. 21 (3): 286–289. doi:10.1016/j.chom.2017.02.001. PMC 6404758. PMID 28279332.: CS1 maint: multiple names: authors allocate (link)